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HAMAP annotation rule: MF_00558
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General rule information

Accession MF_00558
Dates 23-MAY-2002 (Created)
10-OCT-2011 (Last updated, Version 25)
Data class Protein
Predictors HAMAP; MF_00558; [distribution of match scores in UniProtKB];[seed alignment for MF_00558]
Names Succ_CoA_beta


Propagated annotation

Identifier, protein and gene names
Identifier SUCC
Protein name
RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta;
EC=6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit beta;
Short=SCS-beta;
Gene name sucC
Comments
CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

case <FTGroup:1>
COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
end case

PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
SUBUNIT: Heterotetramer of two alpha and two beta subunits (By similarity).
SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit family.

case <Feature:PS50975>
SIMILARITY: Contains 1 ATP-grasp domain.
end case

Cross-references
Pfam PF08442; ATP-grasp_2; 1;
PF00549; Ligase_CoA; 1;
TIGRFAMs TIGR01016; SucCoAbeta; 1;
PROSITE PS50975; ATP_GRASP; 1;
PS01217; SUCCINYL_COA_LIG_3; 1;
Keywords
ATP-binding, Ligase.

case <FTGroup:1>
Magnesium, Manganese, Metal-binding.
end case

Nucleotide-binding, Tricarboxylic acid cycle.

case <OC:Bacillaceae> and <FT:5>
Phosphoprotein.
end case

Gene Ontology
GO:0005524; Molecular function: ATP binding.

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
end case

GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
Features
From: SUCC_BACSU (P80886)
Key     From     To       Description   Condition   FTGroup
DOMAIN     9     244       ATP-grasp      
NP_BIND     35     108       ATP (By similarity)      
 
METAL     197     197       Magnesium or manganese (By similarity)   E   1
METAL     199     199       Magnesium or manganese (By similarity)   N   1
case <OC:Bacillaceae>
Key     From     To       Description   Condition   FTGroup
 
MOD_RES     220     220       Phosphoserine (By similarity)   S  
end case



Additional information

Size range: 364-399 amino acids
Related UniRules: None
Template: P0A836 (SUCC_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ARCFU, STRCO
Plasmid encoded: None
Comments: It is not possible to automatically make a distinction between a bona-fide sucC and mtkA (not shown in alignment).

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UniProtKB rule member sequences