HAMAP rule MF_00562
General rule information
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| Accession | MF_00562 |
| Dates | 31-MAY-2002 (Created)
6-JAN-2022 (Last updated, Version 29) |
| Name | Deacylase_DtdA |
| Scope(s) |
Archaea |
| Template(s) | Q9V2R8 (DTDA_PYRAB); [ Recover all ] |
| Triggered by |
HAMAP; MF_00562 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DTDA |
| Protein name | RecName: Full=D-aminoacyl-tRNA deacylase; EC=3.1.1.96; |
| Gene name | Name=dtdA; |
Comments
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| FUNCTION | D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. |
| CATALYTIC ACTIVITY | Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=3.1.1.96; |
| CATALYTIC ACTIVITY | Reaction=glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala); Xref=Rhea:RHEA:53744, Rhea:RHEA-COMP:9657, Rhea:RHEA-COMP:13640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=3.1.1.96; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the DtdA deacylase family. |
Keywords
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Gene Ontology
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| GO:0008270; Molecular function:zinc ion binding |
| GO:0016788; Molecular function:hydrolase activity, acting on ester bonds |
| GO:0051499; Molecular function:D-aminoacyl-tRNA deacylase activity |
| GO:0019478; Biological process:D-amino acid catabolic process |
Cross-references
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| Pfam | PF04414; tRNA_deacylase; 1; |
| PIRSF | PIRSF016210; UCP016210; 1; |
Features
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Additional information
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| Size range | 237-524 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent HALSA not shown in alignment |