HAMAP

Accession	MF_00563
Dates	4-JUN-2002 (Created) 10-OCT-2011 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_00563; [distribution of match scores in UniProtKB];[seed alignment for MF_00563]

Names

AdoHcyase

Identifier

SAHH

Protein name

RecName: Full=Adenosylhomocysteinase; EC=3.3.1.1; AltName: Full=S-adenosyl-L-homocysteine hydrolase; Short=AdoHcyase;

Gene name

ahcY

FUNCTION: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).

CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

COFACTOR: Binds 1 NAD per subunit (By similarity).

PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the adenosylhomocysteinase family.

Pfam	PF05221; AdoHcyase; 1; PF00670; AdoHcyase_NAD; 1;
PIRSF	PIRSF001109; Ad_hcy_hydrolase; 1;
TIGRFAMs	TIGR00936; AhcY; 1;
PROSITE	PS00738; ADOHCYASE_1; 1; PS00739; ADOHCYASE_2; 1;

Cytoplasm, Hydrolase, NAD, One-carbon metabolism.

GO:0004013; Molecular function: adenosylhomocysteinase activity.
GO:0006730; Biological process: one-carbon metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: SAHH_BURP1 (Q3JY79)
Key		From		To		Description		Condition		FTGroup
NP_BIND		200		202		NAD (By similarity)		T-T-[TA]
NP_BIND		263		268		NAD (By similarity)		G-[YF]-G-x-x-G
NP_BIND		342		344		NAD (By similarity)		[ISA]-G-H
BINDING (Optional)		64		64		Substrate (By similarity)		T
BINDING (Optional)		139		139		Substrate (By similarity)		D
BINDING (Optional)		199		199		Substrate (By similarity)		E
BINDING (Optional)		229		229		Substrate (By similarity)		K
BINDING (Optional)		233		233		Substrate (By similarity)		D
BINDING (Optional)		234		234		NAD (By similarity)		N
BINDING (Optional)		286		286		NAD (By similarity)		E
BINDING (Optional)		321		321		NAD (By similarity)		N
BINDING (Optional)		387		387		NAD (By similarity)		N

Size range:	404-496 amino acids
Related UniRules:	None
Template:	P10760 (SAHH_RAT); P28183 (SAHH_RHOCB); Q58783 (SAHH_METJA); Q3JY79 (SAHH_BURP1): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None