HAMAP rule MF_00565
General rule information
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| Accession | MF_00565 |
| Dates | 29-JUN-2002 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | DltC |
| Scope(s) |
Bacteria |
| Template(s) | P39579 (DLTC_BACSU); P55153 (DLTC_LACRH); Q2FZW4 (DLTC_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_00565 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DLTC |
| Protein name | RecName: Full=D-alanyl carrier protein; Short=DCP; AltName: Full=D-alanine--poly(phosphoribitol) ligase subunit 2; |
| Gene name | Name=dltC; |
Comments
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| FUNCTION | Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. |
| PATHWAY | Cell wall biogenesis; lipoteichoic acid biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| PTM | 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP. |
| SIMILARITY | Belongs to the DltC family. |
Keywords
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Gene Ontology
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| GO:0036370; Molecular function:D-alanyl carrier activity |
| GO:0005737; Cellular component:cytoplasm |
| GO:0070395; Biological process:lipoteichoic acid biosynthetic process |
Cross-references
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Features
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| From: DLTC_BACSU (P39579) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 36 | 36 | /note="O-(pantetheine 4'-phosphoryl)serine" | S | ||||||||
Additional information
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| Size range | 75-83 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |