Annotation rule MF_00572
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General rule information [?]

Accession MF_00572
Dates 12-JUL-2002 (Created)
26-SEP-2014 (Last updated, Version 27)
Name LeuA_type2
Scope Bacteria
Templates P42455 (LEU1_CORGL); P9WQB3 (LEU1_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LEU1
Protein name
RecName: Full=2-isopropylmalate synthase;
EC=2.3.3.13;
AltName: Full=Alpha-IPM synthase;
AltName: Full=Alpha-isopropylmalate synthase;
Gene name
leuA

Comments [?]

Function Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Catalytic activity Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
Pathway Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate; step 1/4.
Subunit Homotetramer.
Similarity Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003852; Molecular function: 2-isopropylmalate synthase activity.
GO:0009098; Biological process: leucine biosynthetic process.

Cross-references [?]

Pfam PF00682; HMGL-like; 1;
TIGRFAMs TIGR00970; LeuA_yeast; 1;
PROSITE PS00815; AIPM_HOMOCIT_SYNTH_1; 1;
PS00816; AIPM_HOMOCIT_SYNTH_2; 1;
PS50991; PYR_CT; 1;

Additional information [?]

Size range 530-675 amino acids
Related rules MF_01025 (LEU1); MF_01028 (CIMA)
Fusion None
Comments Weird insertion in MYCBO and MYCTU (not shown in alignment and not used in size range)