HAMAP

Accession	MF_00575
Dates	31-JUL-2002 (Created) 28-OCT-2011 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_00575; [distribution of match scores in UniProtKB];[seed alignment for MF_00575]

Names

LpxH

Identifier

LPXH

Protein name

RecName: Full=UDP-2,3-diacylglucosamine hydrolase; EC=3.6.1.54; AltName: Full=UDP-2,3-diacylglucosamine diphosphatase;

Gene name

lpxH

FUNCTION: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP (By similarity).

CATALYTIC ACTIVITY: UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + H(2)O = 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP.

PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the lpxH family.

Pfam	PF00149; Metallophos; 1;
TIGRFAMs	TIGR01854; Lipid_A_lpxH; 1;

Cytoplasm, Hydrolase, Lipid synthesis, Lipid A biosynthesis.

GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	234-268 amino acids
Related UniRules:	None
Template:	P43341 (LPXH_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible wrong start in RALSO