HAMAP rule MF_00578

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00578
Accession	MF_00578
Dates	27-AUG-2002 (Created) 3-SEP-2024 (Last updated, Version 24)
Name	Glu_cys_ligase
Scope(s)	Bacteria
Template(s)	P0A6W9 (GSH1_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00578 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GSH1
Protein name	RecName: Full=Glutamate--cysteine ligase; EC=6.3.2.2; AltName: Full=Gamma-ECS; Short=GCS; AltName: Full=Gamma-glutamylcysteine synthetase;
Gene name	Name=gshA;

Comments [?]

CATALYTIC ACTIVITY	Reaction=L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+); Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
PATHWAY	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
SIMILARITY	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004357; Molecular function:glutamate-cysteine ligase activity

GO:0006750; Biological process:glutathione biosynthetic process

Cross-references [?]

Pfam	PF04262; Glu_cys_ligase; 1;
NCBIfam	TIGR01434; Glu_cys_ligase; 1;

Features [?]

Additional information [?]