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HAMAP rule MF_00581

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General rule information [?]

Accession MF_00581
Dates 17-OCT-2002 (Created)
1-JUN-2023 (Last updated, Version 40)
Name Arg_succ_synth_type2
Scope(s) Bacteria
Template(s) P0A6E4 (ASSY_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00581 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ASSY
Protein name RecName: Full=Argininosuccinate synthase;
                 EC=6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name Name=argG;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10932, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57472, ChEBI:CHEBI:57743, ChEBI:CHEBI:456215; EC=6.3.4.5;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
SUBUNITHomotetramer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the argininosuccinate synthase family. Type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004055; Molecular function:argininosuccinate synthase activity
GO:0005524; Molecular function:ATP binding
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
NCBIfam TIGR00032; ArgG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PROSITE PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_ECOLI (P0A6E4)
Key From To Description Tag Condition FTGroup
BINDING 17 25 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
BINDING 43 43 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
A
BINDING 99 99 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
Y
BINDING 129 129 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G
BINDING 131 131 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
T
BINDING 131 131 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
T
BINDING 135 135 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
N
BINDING 135 135 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
N
BINDING 136 136 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D
BINDING 136 136 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
D
BINDING 139 139 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
R
BINDING 192 192 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
S
BINDING 194 194 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D
BINDING 201 201 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
T
BINDING 203 203 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
E
BINDING 280 280 /ligand="L-citrulline"
/ligand_id="ChEBI:CHEBI:57743"
E

Additional information [?]

Size range 444-482 amino acids
Related rules MF_00005
Fusion Nter: None Cter: None
Comments Argininosuccinate synthase type 1 subfamily in MF_00005.



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