HAMAP rule MF_00581
General rule information
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Accession | MF_00581 |
Dates | 17-OCT-2002 (Created)
1-JUN-2023 (Last updated, Version 40) |
Name | Arg_succ_synth_type2 |
Scope(s) |
Bacteria |
Template(s) | P0A6E4 (ASSY_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00581 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ASSY |
Protein name | RecName: Full=Argininosuccinate synthase; EC=6.3.4.5; AltName: Full=Citrulline--aspartate ligase; |
Gene name | Name=argG; |
Comments
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CATALYTIC ACTIVITY | Reaction=ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10932, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57472, ChEBI:CHEBI:57743, ChEBI:CHEBI:456215; EC=6.3.4.5; |
PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. |
SUBUNIT | Homotetramer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the argininosuccinate synthase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0004055; Molecular function:argininosuccinate synthase activity |
GO:0005524; Molecular function:ATP binding |
GO:0006526; Biological process:arginine biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00764; Arginosuc_synth; 1; |
NCBIfam | TIGR00032; ArgG; 1; |
PROSITE | PS00564; ARGININOSUCCIN_SYN_1; 1; |
PROSITE | PS00565; ARGININOSUCCIN_SYN_2; 1; |
Features
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From: ASSY_ECOLI (P0A6E4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 17 | 25 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
BINDING | 43 | 43 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
A | ||||||||
BINDING | 99 | 99 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
Y | ||||||||
BINDING | 129 | 129 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
BINDING | 131 | 131 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
BINDING | 131 | 131 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
T | ||||||||
BINDING | 135 | 135 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
N | ||||||||
BINDING | 135 | 135 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
N | ||||||||
BINDING | 136 | 136 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
BINDING | 136 | 136 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
D | ||||||||
BINDING | 139 | 139 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
R | ||||||||
BINDING | 192 | 192 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
S | ||||||||
BINDING | 194 | 194 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
BINDING | 201 | 201 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
T | ||||||||
BINDING | 203 | 203 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
E | ||||||||
BINDING | 280 | 280 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
E |
Additional information
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Size range | 444-482 amino acids |
Related rules |
MF_00005 |
Fusion | Nter: None Cter: None |
Comments | Argininosuccinate synthase type 1 subfamily in MF_00005. |