HAMAP

Accession	MF_00583
Dates	19-OCT-2002 (Created) 10-OCT-2011 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_00583_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00583_B]

Predictors

HAMAP; MF_00583_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00583_A]

Names

RibP_PPkinase

Identifier

KPRS

Protein name

RecName: Full=Ribose-phosphate pyrophosphokinase; Short=RPPK; EC=2.7.6.1; AltName: Full=Phosphoribosyl pyrophosphate synthase; Short=P-Rib-PP synthase; Short=PRPP synthase;

Gene name

prs

CATALYTIC ACTIVITY: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.

Pfam	PF00156; Pribosyltran; 1;
TIGRFAMs	TIGR01251; RibP_PPkin; 1;
PROSITE	PS00114; PRPP_SYNTHASE; 1;

ATP-binding, Cytoplasm, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Nucleotide biosynthesis, Transferase.

GO:0000287; Molecular function: magnesium ion binding.
GO:0004749; Molecular function: ribose phosphate diphosphokinase activity.
GO:0009156; Biological process: ribonucleoside monophosphate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: KPRS_ECOLI (P0A717)
Key		From		To		Description		Condition		FTGroup
REGION		213		226		5-phosphoribose 1-diphosphate binding (Potential)
METAL		129		129		Magnesium (Potential)		D
METAL		131		131		Magnesium (Potential)		H
METAL		140		140		Magnesium (Potential)		[DN]
METAL		144		144		Magnesium (Potential)		D

From: KPRS_METJA (Q58761)
Key		From		To		Description		Condition		FTGroup
REGION		205		218		5-phosphoribose 1-diphosphate binding (Potential)
METAL		123		123		Magnesium (Potential)		[DEN]
METAL		125		125		Magnesium (Potential)		H

Size range:

309-344 amino acids

Size range:

271-300 amino acids

Related UniRules:	None
Template:	P14193 (KPRS_BACSU); P0A717 (KPRS_ECOLI); O52958 (KPRS_PYRKO); Q58761 (KPRS_METJA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ARCFU, LACLA, LISIN, LISMO, STRP8, STRPN, STRP1
Plasmid encoded:	None
Comments:	Second divergent STRCO not shown in alignment. AQUAE has E instead of D in first magnesium-binding site. DEIRA has lost two of its potential magnesium binding residue.