HAMAP rule MF_00588
General rule information
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Accession | MF_00588 |
Dates | 22-OCT-2002 (Created)
1-JUN-2023 (Last updated, Version 21) |
Name | GatE |
Scope(s) |
Archaea |
Template(s) | O26803 (GATE_METTH); [ Recover all ] |
Triggered by |
HAMAP; MF_00588 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GATE |
Protein name | RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit E; Short=Glu-ADT subunit E; EC=6.3.5.-; |
Gene name | Name=gatE; |
Comments
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FUNCTION | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; |
SUBUNIT | Heterodimer of GatD and GatE. |
SIMILARITY | Belongs to the GatB/GatE family. GatE subfamily. |
Keywords
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Gene Ontology
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GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
GO:0006412; Biological process:translation |
Cross-references
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Pfam | PF02938; GAD; 1; |
Pfam | PF02934; GatB_N; 1; |
Pfam | PF02637; GatB_Yqey; 1; |
NCBIfam | TIGR00134; GatE_arch; 1; |
PROSITE | PS01234; GATB; 1; |
Features
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Additional information
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Size range | 598-642 amino acids |
Related rules |
MF_00121 |
Fusion | Nter: None Cter: None |