HAMAP

Accession	MF_00593
Dates	1-NOV-2002 (Created) 17-AUG-2010 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00593; [distribution of match scores in UniProtKB];[seed alignment for MF_00593]

Names

DltA

Identifier

DLTA

Protein name

RecName: Full=D-alanine--poly(phosphoribitol) ligase subunit 1; EC=6.1.1.13; AltName: Full=D-alanine-D-alanyl carrier protein ligase; Short=DCL; AltName: Full=D-alanine-activating enzyme; Short=DAE;

Gene name

dltA

FUNCTION: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity).

CATALYTIC ACTIVITY: ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).

PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Pfam	PF00501; AMP-binding; 1;
PRINTS	PR00154; AMPBINDING; 1;
TIGRFAMs	TIGR01733; AA-adenyl-dom; 1; TIGR01734; D-ala-DACP-lig; 1;
PROSITE	PS00455; AMP_BINDING; 1;

ATP-binding, Cytoplasm, Ligase, Nucleotide-binding.

GO:0016876; Molecular function: ligase activity, forming aminoacyl-tRNA and related compounds.
GO:0005737; Cellular component: cytoplasm.

Size range:	485-516 amino acids
Related UniRules:	None
Template:	P39581 (DLTA_BACSU)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None