HAMAP

Accession	MF_00596
Dates	4-NOV-2002 (Created) 25-NOV-2009 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00596; [distribution of match scores in UniProtKB];[seed alignment for MF_00596]

Names

GMP_reduct_type1

Identifier

GUAC

Protein name

RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;

Gene name

guaC

FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).

CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Pfam	PF00478; IMPDH; 1;
PIRSF	PIRSF000235; GMP_reductase; 1;
TIGRFAMs	TIGR01305; GMP_reduct_1; 1;
PROSITE	PS00487; IMP_DH_GMP_RED; 1;

Oxidoreductase, NADP, Metal-binding, Potassium.

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

From: GUAC_ECOLI (P60560)
Key		From		To		Description		Condition		FTGroup
NP_BIND		108		131		NADP (By similarity)
NP_BIND		216		239		NADP; ribose moiety (By similarity)
ACT_SITE		186		186		Thioimidate intermediate (By similarity)		C
METAL		181		181		Potassium; via carbonyl oxygen (By similarity)		G
METAL		183		183		Potassium; via carbonyl oxygen (By similarity)		G

Size range:	347-351 amino acids
Related UniRules:	None
Template:	P60560 (GUAC_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None