HAMAP

Accession	MF_00607
Dates	9-DEC-2002 (Created) 10-OCT-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00607; [distribution of match scores in UniProtKB];[seed alignment for MF_00607]

Names

16SrRNA_methyltr_A

Identifier

RSMA

Protein name

RecName: Full=Ribosomal RNA small subunit methyltransferase A; EC=2.1.1.182; AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase;

Protein name

RecName: Full=Probable ribosomal RNA small subunit methyltransferase A; EC=2.1.1.-; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase;

Gene name

rsmA, ksgA

FUNCTION: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity).

CATALYTIC ACTIVITY: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.

FUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.

Pfam	PF00398; RrnaAD; 1;
TIGRFAMs	TIGR00755; KsgA; 1;
PROSITE	PS01131; RRNA_A_DIMETH; 1;

Cytoplasm, RNA-binding, rRNA processing, S-adenosyl-L-methionine, Transferase, Methyltransferase.

GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
GO:0000154; Biological process: rRNA modification.
GO:0005737; Cellular component: cytoplasm.

From: RSMA_ECOLI (P06992)
Key		From		To		Description		Condition		FTGroup
BINDING (Optional)		18		18		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		[NH]
BINDING		20		20		S-adenosyl-L-methionine; via amide nitrogen (By similarity)		[ILVM]
BINDING		45		45		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		G
BINDING		66		66		S-adenosyl-L-methionine (By similarity)		E
BINDING		91		91		S-adenosyl-L-methionine (By similarity)		D
BINDING		113		113		S-adenosyl-L-methionine (By similarity)		N

Size range:	228-330 amino acids
Related UniRules:	None
Template:	P06992 (RSMA_ECOLI); P13956 (ERM_BACSU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None