HAMAP

Accession	MF_00621
Dates	27-FEB-2003 (Created) 30-MAY-2011 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00621; [distribution of match scores in UniProtKB];[seed alignment for MF_00621]

Names

HTH-type_CodY

Identifier

CODY

Protein name

RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY;

Gene name

codY

FUNCTION: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the CodY family.

Pfam	PF06018; CodY; 1; PF08222; HTH_CodY; 1;
TIGRFAMs	TIGR02787; CodY_Gpos; 1;
PIRSF	PIRSF011572; GTP_sensing_CodY; 1;

Cytoplasm, Transcription, Transcription regulation, Repressor, DNA-binding, GTP-binding, Nucleotide-binding.

Phosphoprotein.

GO:0005525; Molecular function: GTP binding.
GO:0045892; Biological process: negative regulation of transcription, DNA-dependent.
GO:0005737; Cellular component: cytoplasm.

From: CODY_LACLA (Q9CJ45)
Key		From		To		Description		Condition		FTGroup
DNA_BIND		206		225		H-T-H motif (Potential)

From: CODY_BACSU (P39779)
Key		From		To		Description		Condition		FTGroup
MOD_RES		215		215		Phosphoserine (By similarity)		S

Size range:	250-262 amino acids
Related UniRules:	None
Template:	P39779 (CODY_BACSU); Q9CJ45 (CODY_LACLA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None