HAMAP

Accession	MF_00624
Dates	11-MAR-2003 (Created) 10-OCT-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00624; [distribution of match scores in UniProtKB];[seed alignment for MF_00624]

Names

GlgC

Identifier

GLGC

Protein name

RecName: Full=Glucose-1-phosphate adenylyltransferase; EC=2.7.7.27; AltName: Full=ADP-glucose pyrophosphorylase; Short=ADPGlc PPase; AltName: Full=ADP-glucose synthase;

Gene name

glgC

FUNCTION: Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity).

CATALYTIC ACTIVITY: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.

PATHWAY: Glycan biosynthesis; glycogen biosynthesis.

SIMILARITY: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

Pfam	PF00483; NTP_transferase; 1; PF00132; Hexapep; 0-4;
TIGRFAMs	TIGR02091; GlgC; 1;
PROSITE	PS00808; ADP_GLC_PYROPHOSPH_1; 1; PS00809; ADP_GLC_PYROPHOSPH_2; 1; PS00810; ADP_GLC_PYROPHOSPH_3; 1;

ATP-binding, Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism, Nucleotide-binding, Nucleotidyltransferase, Transferase.

GO:0008878; Molecular function: glucose-1-phosphate adenylyltransferase activity.
GO:0005978; Biological process: glycogen biosynthetic process.

Size range:	376-476 amino acids
Related UniRules:	None
Template:	P0A6V1 (GLGC_ECOLI); P30521 (GLGC_NOSS1); P64241 (GLGC_MYCTU): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in ALHEH, PSEA6, VIBCH, VIBPA, VIBVU, VIBVY
Plasmid encoded:	None
Comments:	GlgC from M.tuberculosis is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.