HAMAP logo

HAMAP rule MF_00624

Send feedback

General rule information [?]

Accession MF_00624
Dates 11-MAR-2003 (Created)
1-JUN-2023 (Last updated, Version 30)
Name GlgC
Scope(s) Bacteria
Template(s) P0A6V1 (GLGC_ECOLI); P30521 (GLGC_NOSS1); P9WN43 (GLGC_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_00624 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GLGC
Protein name RecName: Full=Glucose-1-phosphate adenylyltransferase;
                 EC=2.7.7.27;
AltName: Full=ADP-glucose pyrophosphorylase;
                 Short=ADPGlc PPase;
AltName: Full=ADP-glucose synthase;
Gene name Name=glgC;

Comments [?]

case <OC:Mycobacterium>
FUNCTIONInvolved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
else
FUNCTIONInvolved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
end case
CATALYTIC ACTIVITY Reaction=alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate; Xref=Rhea:RHEA:12120, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57498, ChEBI:CHEBI:58601; EC=2.7.7.27;
PATHWAYGlycan biosynthesis; glycogen biosynthesis.
case <OC:Enterobacteriaceae>
ACTIVITY REGULATIONAllosterically activated by fructose-1,6- bisphosphate (F16BP) and inhibited by AMP.
end case
case not <OC:Mycobacterium>
SUBUNITHomotetramer.
end case
SIMILARITYBelongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0008878; Molecular function:glucose-1-phosphate adenylyltransferase activity
GO:0005978; Biological process:glycogen biosynthetic process

Cross-references [?]

Pfam PF00483; NTP_transferase; 1;
Pfam PF00132; Hexapep; 0-4;
NCBIfam TIGR02091; GlgC; 1;
PROSITE PS00808; ADP_GLC_PYROPHOSPH_1; 1;
PROSITE PS00809; ADP_GLC_PYROPHOSPH_2; 1;
PROSITE PS00810; ADP_GLC_PYROPHOSPH_3; 1;

Features [?]

From: GLGC_ECOLI (P0A6V1)
Key From To Description Tag Condition FTGroup
BINDING 194 195 /ligand="alpha-D-glucose 1-phosphate"
/ligand_id="ChEBI:CHEBI:58601"
E-K
case <OC:Enterobacteriaceae>
BINDING 419 423 /ligand="beta-D-fructose 1,6-bisphosphate"
/ligand_id="ChEBI:CHEBI:32966"
R-[ED]-x(2)-R
BINDING 429 431 /ligand="beta-D-fructose 1,6-bisphosphate"
/ligand_id="ChEBI:CHEBI:32966"
Q-E-R
BINDING 39 39 /ligand="beta-D-fructose 1,6-bisphosphate"
/ligand_id="ChEBI:CHEBI:32966"
K
BINDING 40 40 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
R
BINDING 46 46 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
H
BINDING 52 52 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
R
end case
BINDING 114 114 /ligand="alpha-D-glucose 1-phosphate"
/ligand_id="ChEBI:CHEBI:58601"
Y
case <OC:Enterobacteriaceae>
BINDING 130 130 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
R
end case
BINDING 179 179 /ligand="alpha-D-glucose 1-phosphate"
/ligand_id="ChEBI:CHEBI:58601"
G
BINDING 212 212 /ligand="alpha-D-glucose 1-phosphate"
/ligand_id="ChEBI:CHEBI:58601"
S
case <OC:Enterobacteriaceae>
BINDING 370 370 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
[ED]
BINDING 386 386 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"
[RK]
end case
SITE 74 74 /note="Could play a key role in the communication between the regulatory and the substrate sites" Q
SITE 113 113 /note="Could play a key role in the communication between the regulatory and the substrate sites" [WF]

Additional information [?]

Size range 376-476 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments GlgC from M.tuberculosis is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.



View rule in raw text format (no links)