Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP annotation rule: MF_00627
Send feedback new

General rule information

Accession MF_00627
Dates 24-MAR-2003 (Created)
10-OCT-2011 (Last updated, Version 21)
Data class Protein
Predictors HAMAP; MF_00627; [distribution of match scores in UniProtKB];[seed alignment for MF_00627]
Names Thr_dehydrog


Propagated annotation

Identifier, protein and gene names
Identifier TDH

case <OC:Bacteria>
Protein name
RecName: Full=L-threonine 3-dehydrogenase;
EC=1.1.1.103;
end case


case <OC:Archaea>
Protein name
RecName: Full=Probable L-threonine 3-dehydrogenase;
EC=1.1.1.103;
end case

Gene name tdh
Comments
CATALYTIC ACTIVITY: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.

case <FTGroup:1> and <FTGroup:2>
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
end case

PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.

case <OC:Bacteria>
SUBUNIT: Homotetramer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.
Cross-references
Pfam PF08240; ADH_N; 1;
PF00107; ADH_zinc_N; 1;
TIGRFAMs TIGR00692; Tdh; 1;
PROSITE PS00059; ADH_ZINC; 1;
Keywords
Cytoplasm, Oxidoreductase.

case <FTGroup:1> or <FTGroup:2>
Zinc, Metal-binding.
end case

NAD.
Gene Ontology
GO:0008743; Molecular function: L-threonine 3-dehydrogenase activity.

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case

GO:0006567; Biological process: threonine catabolic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: TDH_ECOLI (P07913)
Key     From     To       Description   Condition   FTGroup
METAL     38     38       Zinc 1; catalytic (By similarity)   C   1
METAL     63     63       Zinc 1; catalytic (By similarity)   H   1
 
METAL     93     93       Zinc 2 (By similarity)   C   2
METAL     96     96       Zinc 2 (By similarity)   C   2
METAL     99     99       Zinc 2 (By similarity)   C   2
METAL     107     107       Zinc 2 (By similarity)   C   2
 
METAL     148     148       Zinc 1; catalytic (By similarity)   [DE]   1


Additional information

Size range: 340-361 amino acids
Related UniRules: None
Template: P07913 (TDH_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

View rule in raw text format (no links)



UniProtKB rule member sequences