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Annotation rule MF_00635
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General rule information [?]

Accession MF_00635
Dates 16-APR-2003 (Created)
26-SEP-2014 (Last updated, Version 12)
Name dUTPase_arch
Scope Archaea
Template Q58502 (DUT_METJA)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DUT
Protein name
RecName: Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase;
Short=dUTPase;
EC=3.6.1.23;
AltName: Full=dUTP pyrophosphatase;
Gene name
dut

Comments [?]

Function This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity dUTP + H(2)O = dUMP + diphosphate.
Pathway Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Similarity Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.

Cross-references [?]

Pfam PF00692; dUTPase; 1;

Additional information [?]

Size range 150-171 amino acids
Related rules MF_00146 (DCD)
Fusion None