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HAMAP annotation rule: MF_00638
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General rule information

Accession MF_00638
Dates 17-APR-2003 (Created)
29-MAR-2011 (Last updated, Version 12)
Data class Protein
Predictors HAMAP; MF_00638; [distribution of match scores in UniProtKB];[seed alignment for MF_00638]
Names Anti_sigma_B


Propagated annotation

Identifier, protein and gene names
Identifier RSBW
Protein name
RecName: Full=Serine-protein kinase rsbW;
EC=2.7.11.1;
AltName: Full=Anti-sigma-B factor;
AltName: Full=Sigma-B negative effector rsbW;
Gene name rsbW
Comments
FUNCTION: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Belongs to the anti-sigma-factor family.
Cross-references
Pfam PF02518; HATPase_c; 1;
Keywords
ATP-binding, Kinase, Nucleotide-binding, Transferase.
Gene Ontology
GO:0004672; Molecular function: protein kinase activity.
GO:0010468; Biological process: regulation of gene expression.


Additional information

Size range: 157-162 amino acids
Related UniRules: MF_00637 (SP2AB)
Template: P17904 (RSBW_BACSU)
Scope: Bacteria; Bacillales
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences