HAMAP

Accession	MF_00639
Dates	26-APR-2003 (Created) 10-OCT-2011 (Last updated, Version 27)

Name

MurD

Scope

Bacteria

Triggered by

HAMAP; MF_00639 (Get profile general information and statistics)

Identifier

MURD

Protein name

RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=D-glutamic acid-adding enzyme; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;

Gene name

murD

FUNCTION	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity).
CATALYTIC ACTIVITY	ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
SUBCELLULAR LOCATION	Cytoplasm (By similarity).
SIMILARITY	Belongs to the MurCDEF family.

ATP-binding
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis

GO:0005524; Molecular function: ATP binding.
GO:0008764; Molecular function: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF01225; Mur_ligase; 1;
	PF02875; Mur_ligase_C; 1;
TIGRFAMs	TIGR01087; MurD; 1;

From: MURD_ECOLI (P14900)

Key

From

To

Description

Tag

Condition

FTGroup

NP_BIND

112

118

ATP (Potential)

G-[STA]-x-[GA]-K-[GST]-[ST]

Size range:	402-517 amino acids
Related Rules:	None
Templates:	P14900 (MURD_ECOLI); Q9HVZ9 (MURD_PSEAE): [Recover all]
Fusion:	None
Comments:	Insertion in POLSJ (not shown in alignment and not used in size range)

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