HAMAP

Accession	MF_00639
Dates	26-APR-2003 (Created) 10-OCT-2011 (Last updated, Version 27)

Data class

Protein

Predictors

HAMAP; MF_00639; [distribution of match scores in UniProtKB];[seed alignment for MF_00639]

Names

MurD

Identifier

MURD

Protein name

RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9; AltName: Full=D-glutamic acid-adding enzyme; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;

Gene name

murD

FUNCTION: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity).

CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the MurCDEF family.

Pfam	PF01225; Mur_ligase; 1; PF02875; Mur_ligase_C; 1;
TIGRFAMs	TIGR01087; MurD; 1;

ATP-binding, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Cytoplasm, Ligase, Nucleotide-binding, Peptidoglycan synthesis.

GO:0005524; Molecular function: ATP binding.
GO:0008764; Molecular function: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: MURD_ECOLI (P14900)
Key		From		To		Description		Condition		FTGroup
NP_BIND		112		118		ATP (Potential)		G-[STA]-x-[GA]-K-[GST]-[ST]

Size range:	402-517 amino acids
Related UniRules:	None
Template:	P14900 (MURD_ECOLI); Q9HVZ9 (MURD_PSEAE): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Insertion in POLSJ (not shown in alignment and not used in size range)