HAMAP rule MF_00668
General rule information
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Accession | MF_00668 |
Dates | 7-JUL-2003 (Created)
1-JUN-2023 (Last updated, Version 26) |
Name | BioW |
Scope(s) |
Bacteria Archaea |
Template(s) | P22822 (BIOW_LYSSH); [ Recover all ] |
Triggered by |
HAMAP; MF_00668 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | BIOW |
Protein name | RecName: Full=6-carboxyhexanoate--CoA ligase; EC=6.2.1.14; AltName: Full=Pimeloyl-CoA synthase; |
Gene name | Name=bioW; |
Comments
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FUNCTION | Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. |
CATALYTIC ACTIVITY | Reaction=ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:14781, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:36165, ChEBI:CHEBI:57287, ChEBI:CHEBI:57360, ChEBI:CHEBI:456215; EC=6.2.1.14; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the BioW family. |
Keywords
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Gene Ontology
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GO:0042410; Molecular function:6-carboxyhexanoate-CoA ligase activity |
GO:0000287; Molecular function:magnesium ion binding |
GO:0009102; Biological process:biotin biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 228-259 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: MF_01693 (bioF) |