HAMAP rule MF_00688

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00688
Accession	MF_00688
Dates	24-JUL-2003 (Created) 2-SEP-2024 (Last updated, Version 26)
Name	Leu_Phe_trans
Scope(s)	Bacteria
Template(s)	P0A8P1 (LFTR_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00688 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LFTR
Protein name	RecName: Full=Leucyl/phenylalanyl-tRNA--protein transferase; EC=2.3.2.6; AltName: Full=L/F-transferase; AltName: Full=Leucyltransferase; AltName: Full=Phenyalanyltransferase;
Gene name	Name=aat;

Comments [?]

FUNCTION	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
CATALYTIC ACTIVITY	Reaction=N-terminal L-lysyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) + H(+); Xref=Rhea:RHEA:12340, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12670, Rhea:RHEA-COMP:12671, ChEBI:CHEBI:15378, ChEBI:CHEBI:65249, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133043; EC=2.3.2.6;
CATALYTIC ACTIVITY	Reaction=N-terminal L-arginyl-[protein] + L-leucyl-tRNA(Leu) = N- terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) + H(+); Xref=Rhea:RHEA:50416, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12672, Rhea:RHEA-COMP:12673, ChEBI:CHEBI:15378, ChEBI:CHEBI:64719, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133044; EC=2.3.2.6;
CATALYTIC ACTIVITY	Reaction=L-phenylalanyl-tRNA(Phe) + an N-terminal L-alpha-aminoacyl- [protein] = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe); Xref=Rhea:RHEA:43632, Rhea:RHEA-COMP:9668, Rhea:RHEA- COMP:9699, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10637, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:78597, ChEBI:CHEBI:83561; EC=2.3.2.6;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the L/F-transferase family.

Keywords [?]

Gene Ontology [?]

GO:0008914; Molecular function:leucyl-tRNA--protein transferase activity

GO:0030163; Biological process:protein catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF03588; Leu_Phe_trans; 1;
NCBIfam	TIGR00667; Aat; 1;

Features [?]

Additional information [?]