HAMAP rule MF_00689
General rule information
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Accession | MF_00689 |
Dates | 25-JUL-2003 (Created)
28-JUL-2023 (Last updated, Version 23) |
Name | Bpt |
Scope(s) |
Bacteria |
Template(s) | Q8DAR7 (BPT_VIBVU); Q8UG81 (BPT_AGRFC); Q983E4 (BPT_RHILO); [ Recover all ] |
Triggered by |
HAMAP; MF_00689 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | BPT |
Protein name | RecName: Full=Aspartate/glutamate leucyltransferase; EC=2.3.2.29; |
Gene name | Name=bpt; |
Comments
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FUNCTION | Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. |
CATALYTIC ACTIVITY | Reaction=L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:50412, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12664, Rhea:RHEA-COMP:12668, ChEBI:CHEBI:15378, ChEBI:CHEBI:64721, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133041; EC=2.3.2.29; |
CATALYTIC ACTIVITY | Reaction=L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:50420, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12669, Rhea:RHEA-COMP:12674, ChEBI:CHEBI:15378, ChEBI:CHEBI:64720, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133042; EC=2.3.2.29; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the R-transferase family. Bpt subfamily. |
Keywords
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Gene Ontology
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GO:0008914; Molecular function:leucyl-tRNA--protein transferase activity |
GO:0030163; Biological process:protein catabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF04377; ATE_C; 1; |
Pfam | PF04376; ATE_N; 1; |
PIRSF | PIRSF037208; ATE_pro_prd; 1; |
Features
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Additional information
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Size range | 200-325 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |