HAMAP rule MF_00706
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00706 |
| Accession | MF_00706 |
| Dates | 1-SEP-2003 (Created)
18-NOV-2019 (Last updated, Version 25) |
| Name | Ecotin |
| Scope(s) |
Bacteria |
| Template(s) | P23827 (ECOT_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00706 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ECOT |
| Protein name | RecName: Full=Ecotin; Flags: Precursor; |
| Gene name | Name=eco; |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. |
| else | |
| FUNCTION | General inhibitor of family S1 serine proteases. |
| end case | |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the protease inhibitor I11 (ecotin) family. |
Keywords
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| case <FT:2> | |
| Disulfide bond | |
| end case | |
| Protease inhibitor | |
| Serine protease inhibitor | |
| Periplasm | |
| Signal | |
Gene Ontology
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| GO:0004867; Molecular function:serine-type endopeptidase inhibitor activity |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
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Features
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| From: ECOT_ECOLI (P23827) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 104 | 105 | /note="Reactive bond" | x-M | ||||||||
| DISULFID | 70 | 107 | C-x*-C | |||||||||
Additional information
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| Size range | 156-183 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |