HAMAP rule MF_00708

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00708
Accession	MF_00708
Dates	9-SEP-2003 (Created) 20-AUG-2024 (Last updated, Version 29)
Name	Fumarate_red_C
Scope(s)	Bacteria Gammaproteobacteria Mycobacterium
Template(s)	P0A8Q0 (FRDC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00708 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	FRDC
case <OC:Enterobacterales>
Protein name	RecName: Full=Fumarate reductase subunit C; AltName: Full=Fumarate reductase 15 kDa hydrophobic protein; AltName: Full=Quinol-fumarate reductase subunit C; Short=QFR subunit C;
else
Protein name	RecName: Full=Fumarate reductase subunit C; AltName: Full=Quinol-fumarate reductase subunit C; Short=QFR subunit C;
end case
Gene name	Name=frdC;

Comments [?]

case <OC:Enterobacterales>
FUNCTION	Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
else
FUNCTION	Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
end case
SUBUNIT	Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the FrdC family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005886; Cellular component:plasma membrane

GO:0045283; Cellular component:fumarate reductase complex

GO:0000104; Molecular function:succinate dehydrogenase activity

Cross-references [?]

Pfam	PF02300; Fumarate_red_C; 1;
General	Transmembrane; -; 3;

Features [?]

Additional information [?]