HAMAP

Accession	MF_00711
Dates	19-SEP-2003 (Created) 9-DEC-2011 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_00711; [distribution of match scores in UniProtKB];[seed alignment for MF_00711]

Names

GcvP

Identifier

GCSP

Protein name

RecName: Full=Glycine dehydrogenase [decarboxylating]; EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein; AltName: Full=Glycine decarboxylase;

Gene name

gcvP

FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).

CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).

COFACTOR: Pyridoxal phosphate (By similarity).

SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity).

SIMILARITY: Belongs to the GcvP family.

Pfam	PF02347; GDC-P; 1;
TIGRFAMs	TIGR00461; GcvP; 1;

Oxidoreductase, Pyridoxal phosphate.

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

From: GCSP_ECOLI (P33195)
Key		From		To		Description		Condition		FTGroup
MOD_RES		708		708		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	932-993 amino acids
Related UniRules:	MF_00712 (GCSPA); MF_00713 (GCSPB)
Template:	P33195 (GCSP_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEAE, PSEPK
Plasmid encoded:	None