HAMAP

Accession	MF_00712
Dates	1-OCT-2003 (Created) 9-DEC-2011 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_00712; [distribution of match scores in UniProtKB];[seed alignment for MF_00712]

Names

GcvPA

Identifier

GCSPA

Protein name

RecName: Full=Probable glycine dehydrogenase [decarboxylating] subunit 1; EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein subunit 1; AltName: Full=Glycine decarboxylase subunit 1;

Gene name

gcvPA

FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).

CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).

SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits (By similarity).

SIMILARITY: Belongs to the GcvP family. N-terminal subunit subfamily.

Pfam	PF02347; GDC-P; 1;

Oxidoreductase.

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

Size range:	433-471 amino acids
Related UniRules:	MF_00711 (GCSP)
Template:	P33195 (GCSP_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None