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HAMAP annotation rule: MF_00723
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General rule information

Accession MF_00723
Dates 1-NOV-2003 (Created)
10-OCT-2011 (Last updated, Version 18)
Data class Protein
Predictors HAMAP; MF_00723; [distribution of match scores in UniProtKB];[seed alignment for MF_00723]
Names Formald_GSH


Propagated annotation

Identifier, protein and gene names
Identifier GFA
Protein name
RecName: Full=Glutathione-dependent formaldehyde-activating enzyme;
EC=4.4.1.22;
AltName: Full=S-(hydroxymethyl)glutathione synthase;
Gene name gfa
Comments
FUNCTION: Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity).
CATALYTIC ACTIVITY: S-(hydroxymethyl)glutathione = glutathione + formaldehyde.

case <FTGroup:1>
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
end case

PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.
SIMILARITY: Belongs to the gfa family.
Cross-references
Pfam PF04828; GFA; 1;
PIRSF PIRSF033318; Formald_GSH; 1;
TIGRFAMs TIGR02820; Formald_GSH; 1;
Keywords
Lyase.

case <FTGroup:1>
Metal-binding, Zinc.
end case

Gene Ontology
GO:0051907; Molecular function: S-(hydroxymethyl)glutathione synthase activity.
GO:0046294; Biological process: formaldehyde catabolic process.

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Features
From: GFA_PARDE (Q51669)
Key     From     To       Description   Condition   FTGroup
METAL     31     31       Zinc 1; structural (By similarity)   C   1
METAL     33     33       Zinc 1; structural (By similarity)   C   1
METAL     52     52       Zinc 2; catalytic (By similarity)   C   1
METAL     54     54       Zinc 2; catalytic (By similarity)   C   1
METAL     57     57       Zinc 2; catalytic (By similarity)   C   1
METAL     99     99       Zinc 1; structural (By similarity)   C   1
METAL     102     102       Zinc 1; structural (By similarity)   C   1


Additional information

Size range: 187-194 amino acids
Related UniRules: None
Template: Q51669 (GFA_PARDE)
Scope: Bacteria; Proteobacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: in RHIME

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UniProtKB rule member sequences