HAMAP rule MF_00725

General rule information [?]

Accession	MF_00725
Dates	5-NOV-2003 (Created) 28-NOV-2023 (Last updated, Version 27)
Name	FlhD
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0A8S9 (FLHD_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00725 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	FLHD
Protein name	RecName: Full=Flagellar transcriptional regulator FlhD;
Gene name	Name=flhD;

Comments [?]

FUNCTION	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
SUBUNIT	Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
SUBCELLULAR LOCATION	Cytoplasm.
DOMAIN	The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.
SIMILARITY	Belongs to the FlhD family.

Keywords [?]

Activator
Bacterial flagellum biogenesis
Cytoplasm
case <FT:1>
Disulfide bond
end case
DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding

GO:0006355; Biological process:regulation of DNA-templated transcription

GO:1902208; Biological process:regulation of bacterial-type flagellum assembly

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF05247; FlhD; 1;

Features [?]

From: FLHD_ECOLI (P0A8S9)

Key

From

Description

Tag

Condition

FTGroup

DISULFID

/note="Interchain"

Additional information [?]