HAMAP

Accession	MF_00725
Dates	5-NOV-2003 (Created) 8-JUN-2011 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00725; [distribution of match scores in UniProtKB];[seed alignment for MF_00725]

Names

FlhD

Identifier

FLHD

Protein name

RecName: Full=Flagellar transcriptional regulator FlhD;

Gene name

flhD

FUNCTION: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity).

SUBUNIT: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

DOMAIN: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA (By similarity).

SIMILARITY: Belongs to the FlhD family.

Pfam	PF05247; FlhD; 1;

Activator, Bacterial flagellum biogenesis, Cytoplasm.

Disulfide bond.

DNA-binding, Transcription, Transcription regulation.

GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of transcription, DNA-dependent.
GO:0030092; Biological process: regulation of flagellum assembly.
GO:0005737; Cellular component: cytoplasm.

From: FLHD_ECOLI (P0A8S9)
Key		From		To		Description		Condition		FTGroup
DISULFID		65		65		Interchain (By similarity)		C

Size range:	85-127 amino acids
Related UniRules:	None
Template:	P0A8S9 (FLHD_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALSO, RALP1