HAMAP rule MF_00731
General rule information
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Accession | MF_00731 |
Dates | 20-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 29) |
Name | MenE |
Scope(s) |
Bacteria Archaea |
Template(s) | P23971 (MENE_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_00731 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MENE |
Protein name | RecName: Full=2-succinylbenzoate--CoA ligase; EC=6.2.1.26; AltName: Full=o-succinylbenzoyl-CoA synthetase; Short=OSB-CoA synthetase; |
Gene name | Name=menE; |
Comments
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FUNCTION | Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). |
CATALYTIC ACTIVITY | Reaction=2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:17009, ChEBI:CHEBI:18325, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57364, ChEBI:CHEBI:456215; EC=6.2.1.26; |
PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7. |
case not <OC:Cyanobacteriota> | |
PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
else case <OC:Cyanobacteriota> | |
PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
end case | |
SIMILARITY | Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. |
Keywords
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ATP-binding | |
Ligase | |
case not <OC:Cyanobacteriota> | |
Menaquinone biosynthesis | |
end case | |
Nucleotide-binding |
Gene Ontology
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GO:0008756; Molecular function:o-succinylbenzoate-CoA ligase activity | |
case not <OCellular component:Cyanobacteriota> | |
GO:0009234; Biological process:menaquinone biosynthetic process | |
else case <OCellular component:Cyanobacteriota> | |
GO:0042372; Biological process:phylloquinone biosynthetic process | |
end case |
Cross-references
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Pfam | PF00501; AMP-binding; 1; |
Pfam | PF13193; AMP-binding_C; 1; |
NCBIfam | TIGR01923; MenE; 1; |
PROSITE | PS00455; AMP_BINDING; 1; |
Features
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Additional information
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Size range | 438-514 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |