HAMAP rule MF_00741
General rule information
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Accession | MF_00741 |
Dates | 27-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 31) |
Name | AIRS |
Scope(s) |
Bacteria Archaea |
Template(s) | P08178 (PUR5_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00741 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PUR5 |
Protein name | RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3.1; AltName: Full=AIR synthase; AltName: Full=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; |
Gene name | Name=purM; |
Comments
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CATALYTIC ACTIVITY | Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981, ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1; |
PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 2/2. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the AIR synthase family. |
Keywords
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Gene Ontology
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GO:0004641; Molecular function:phosphoribosylformylglycinamidine cyclo-ligase activity |
GO:0006189; Biological process:'de novo' IMP biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00586; AIRS; 1; |
Pfam | PF02769; AIRS_C; 1; |
NCBIfam | TIGR00878; PurM; 1; |
NCBIfam | TIGR01847; Bacteriocin_sig; 1; |
Features
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Additional information
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Size range | 290-430 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |