HAMAP rule MF_00766
General rule information
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Accession | MF_00766 |
Dates | 8-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37) |
Name | PGT_MtgA |
Scope(s) |
Bacteria |
Template(s) | P46022 (MTGA_ECOLI); Q48465 (MTGA_KLEOX); [ Recover all ] |
Triggered by |
HAMAP; MF_00766 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTGA |
Protein name | RecName: Full=Biosynthetic peptidoglycan transglycosylase; EC=2.4.1.129; AltName: Full=Glycan polymerase; AltName: Full=Peptidoglycan glycosyltransferase MtgA; Short=PGT; |
Gene name | Name=mtgA; |
Comments
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FUNCTION | Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. |
CATALYTIC ACTIVITY | Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
else | |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the glycosyltransferase 51 family. |
Keywords
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case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
Cell inner membrane | |
end case | |
Cell membrane | |
Cell shape | |
Cell wall biogenesis/degradation | |
Glycosyltransferase | |
Membrane | |
Peptidoglycan synthesis | |
Transferase | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF00912; Transgly; 1; |
NCBIfam | TIGR02070; Mono_pep_trsgly; 1; |
General | Transmembrane; -; 1; |
Features
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Additional information
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Size range | 190-300 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |