HAMAP

Accession	MF_00785
Dates	24-MAY-2004 (Created) 18-MAR-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00785; [distribution of match scores in UniProtKB];[seed alignment for MF_00785]

Names

CbiX

Identifier

CBIX

Protein name

RecName: Full=Sirohydrochlorin cobaltochelatase; EC=4.99.1.3; AltName: Full=CbiXS;

Gene name

cbiX

FUNCTION: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (By similarity).

CATALYTIC ACTIVITY: Cobalt-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Co(2+).

PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10.

SUBUNIT: Homodimer or homotetramer (By similarity).

SIMILARITY: Belongs to the CbiX family. CbiXS subfamily.

Pfam	PF01903; CbiX; 1;

Cobalamin biosynthesis, Lyase.

Metal-binding, Cobalt.

GO:0016852; Molecular function: sirohydrochlorin cobaltochelatase activity.
GO:0019251; Biological process: anaerobic cobalamin biosynthetic process.

GO:0050897; Molecular function: cobalt ion binding.

From: CBIX_ARCFU (O29537)
Key		From		To		Description		Condition		FTGroup
REGION		69		74		Substrate binding (By similarity)
ACT_SITE		10		10		Proton acceptor (Potential)		H
METAL		10		10		Cobalt (By similarity)		H
METAL		74		74		Cobalt (By similarity)		H
BINDING		46		46		Substrate (By similarity)		[RKQE]

Size range:	120-144 amino acids
Related UniRules:	None
Template:	O29537 (CBIX_ARCFU); O27448 (CBIX_METTH); P61816 (CBIX_METBF): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	HALSA has a protein with two tandem copies of a cbiX domain, resembling CbiK arrangement.