Annotation rule MF_00785
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General rule information [?]

Accession MF_00785
Dates 24-MAY-2004 (Created)
18-MAR-2011 (Last updated, Version 19)
Name CbiX
Scope Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CBIX
Protein name
RecName: Full=Sirohydrochlorin cobaltochelatase;
EC=4.99.1.3;
AltName: Full=CbiXS;
Gene name
cbiX

Comments [?]

Function Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (By similarity).
Catalytic activity Cobalt-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Co(2+).
Pathway Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route); step 1/10.
Subunit Homodimer or homotetramer (By similarity).
Similarity Belongs to the CbiX family. CbiXS subfamily.

Keywords [?]

case <FT:2>
end case

Gene Ontology [?]

GO:0016852; Molecular function: sirohydrochlorin cobaltochelatase activity.
GO:0019251; Biological process: anaerobic cobalamin biosynthetic process.
case <FT:2>
GO:0050897; Molecular function: cobalt ion binding.
end case

Cross-references [?]

Pfam PF01903; CbiX; 1;

Features [?]

From: CBIX_ARCFU (O29537)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     69     74       Substrate binding (By similarity)        
ACT_SITE     10     10       Proton acceptor (Potential)     H  
METAL     10     10       Cobalt (By similarity)     H  
METAL     74     74       Cobalt (By similarity)     H  
BINDING     46     46       Substrate (By similarity)     [RKQE]  

Additional information [?]

Size range 120-144 amino acids
Related rules None
Templates O29537 (CBIX_ARCFU); O27448 (CBIX_METTH); P61816 (CBIX_METBF): [Recover all]
Fusion None
Comments HALSA has a protein with two tandem copies of a cbiX domain, resembling CbiK arrangement.