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HAMAP annotation rule: MF_00809
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General rule information

Accession MF_00809
Dates 6-APR-2005 (Created)
17-AUG-2010 (Last updated, Version 13)
Data class Protein
Predictors HAMAP; MF_00809; [distribution of match scores in UniProtKB];[seed alignment for MF_00809]
Names ADP_glucokinase


Propagated annotation

Identifier, protein and gene names
Identifier GLKA
Protein name
RecName: Full=ADP-dependent glucokinase;
Short=ADP-GK;
Short=ADPGK;
EC=2.7.1.147;
Gene name glkA
Comments
FUNCTION: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor (By similarity).
CATALYTIC ACTIVITY: ADP + D-glucose = AMP + D-glucose 6-phosphate.
PATHWAY: Carbohydrate degradation; glycolysis.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the ADP-dependent glucokinase family.

case <Feature:PS51255>
SIMILARITY: Contains 1 ADPK (ADP-dependent kinase) domain.
end case

Cross-references
Pfam PF04587; ADP_PFK_GK; 1;
PROSITE PS51255; ADPK; 1; trigger=PRU00584;
Keywords
Cytoplasm, Carbohydrate metabolism, Glucose metabolism, Glycolysis, Kinase, Transferase.
Gene Ontology
GO:0004340; Molecular function: glucokinase activity.
GO:0006096; Biological process: glycolysis.
GO:0005737; Cellular component: cytoplasm.
Features
From: GLKA_PYRFU (Q9V2Z6)
Key     From     To       Description   Condition   FTGroup
NP_BIND     342     344       ADP (By similarity)   H-T-Y  
NP_BIND     438     442       ADP (By similarity)   I-G-D-T-I  
ACT_SITE     440     440       Proton acceptor (By similarity)   D  
BINDING     30     30       Glucose (By similarity)   N  
BINDING     34     34       Glucose (By similarity)   D  
BINDING     88     88       Glucose (By similarity)   E  
BINDING     113     113       Glucose (By similarity)   Q  
BINDING     176     176       Glucose (By similarity)   H  
BINDING     197     197       Glucose (By similarity)   R  
BINDING     292     292       ADP (By similarity)   N  
BINDING     342     342       ADP (By similarity)   H  
BINDING     343     343       ADP; via carbonyl oxygen (By similarity)   T  
BINDING     429     429       ADP; via carbonyl oxygen (By similarity)   V  
BINDING     440     440       ADP (By similarity)   D  
BINDING     440     440       Glucose (By similarity)   D  


Additional information

Size range: 452-467 amino acids
Related UniRules: MF_00561 (K6PF)
Template: Q9V2Z6 (GLKA_PYRFU); O58328 (GLKA_PYRHO); Q7M537 (GLKA_THELI): [Recover all]
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences