HAMAP

Accession	MF_00811
Dates	30-JUN-2005 (Created) 11-OCT-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00811; [distribution of match scores in UniProtKB];[seed alignment for MF_00811]

Names

DapD

Identifier

DAPD

Protein name

RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; EC=2.3.1.117; AltName: Full=Tetrahydrodipicolinate N-succinyltransferase; Short=THDP succinyltransferase; Short=THP succinyltransferase; Short=Tetrahydropicolinate succinylase;

Gene name

dapD

CATALYTIC ACTIVITY: Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.

SUBUNIT: Homotrimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the transferase hexapeptide repeat family.

Pfam	PF00132; Hexapep; 5;
TIGRFAMs	TIGR00965; DapD; 1;
PROSITE	PS00101; HEXAPEP_TRANSFERASES; 1;

Acyltransferase, Amino-acid biosynthesis, Cytoplasm, Diaminopimelate biosynthesis, Lysine biosynthesis, Repeat, Transferase.

GO:0008666; Molecular function: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0005737; Cellular component: cytoplasm.

From: DAPD_UNKP (P56220)
Key		From		To		Description		Condition		FTGroup
BINDING		104		104		Substrate (By similarity)		R
BINDING		141		141		Substrate (By similarity)		D

Size range:	271-289 amino acids
Related UniRules:	None
Template:	P56220 (DAPD_UNKP); P0A9D8 (DAPD_ECOLI); Q8X8Y7 (DAPD_ECO57): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	There is a second family of DapD (see MF_02122).