HAMAP

Accession	MF_00812
Dates	22-AUG-2005 (Created) 25-NOV-2010 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_00812; [distribution of match scores in UniProtKB];[seed alignment for MF_00812]

Names

Thiopur_methtran

Identifier

TPMT

Protein name

RecName: Full=Thiopurine S-methyltransferase; EC=2.1.1.67; AltName: Full=Thiopurine methyltransferase;

Gene name

tpm

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the methyltransferase superfamily. TPMT family.

Pfam	PF05724; TPMT; 1;

Cytoplasm, Methyltransferase, S-adenosyl-L-methionine, Transferase.

GO:0008119; Molecular function: thiopurine S-methyltransferase activity.
GO:0005737; Cellular component: cytoplasm.

From: TPMT_VIBCH (Q9KSN0)
Key		From		To		Description		Condition		FTGroup
BINDING		11		11		S-adenosyl-L-methionine (By similarity)		W
BINDING		46		46		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		[LM]
BINDING		67		67		S-adenosyl-L-methionine (By similarity)		E
BINDING		122		122		S-adenosyl-L-methionine (By similarity)		R

Size range:	213-235 amino acids
Related UniRules:	None
Template:	O86262 (TPMT_PSESJ)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None