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HAMAP rule MF_00823

General rule information [?]

Accession	MF_00823
Dates	6-FEB-2006 (Created) 21-MAY-2024 (Last updated, Version 30)
Name	AcetylCoA_CT_alpha
Scope(s)	Bacteria Plastid
Template(s)	P0ABD5 (ACCA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00823 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ACCA
Protein name	RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Short=ACCase subunit alpha; Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha; EC=2.1.3.15;
Gene name	Name=accA;

Comments [?]

FUNCTION	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
CATALYTIC ACTIVITY	Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15;
PATHWAY	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
SUBUNIT	Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
case <OG:Chloroplast>
SUBCELLULAR LOCATION	Plastid, chloroplast.
end case
case not <OG:Chloroplast>
SUBCELLULAR LOCATION	Cytoplasm.
end case
SIMILARITY	Belongs to the AccA family.

Keywords [?]

Gene Ontology [?]

GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity
GO:2001295; Biological process:malonyl-CoA biosynthetic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Features [?]

Additional information [?]

Size range	255-368 amino acids
Related rules	None
Fusion	Nter: MF_01395 (accD) Cter: None
Comments	A few Bacillota encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations. The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes.