HAMAP

Accession	MF_00825
Dates	21-JUN-2006 (Created) 17-AUG-2010 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_00825; [distribution of match scores in UniProtKB];[seed alignment for MF_00825]

Names

3_HAO

Identifier

3HAO

Protein name

RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase; EC=1.13.11.6; AltName: Full=3-hydroxyanthranilate oxygenase; Short=3-HAO; AltName: Full=3-hydroxyanthranilic acid dioxygenase; Short=HAD;

FUNCTION: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity).

CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.

COFACTOR: Binds 2 Fe(2+) ions per subunit (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the 3-HAO family.

Pfam	PF06052; 3-HAO; 1;

Dioxygenase, Iron, Metal-binding, Oxidoreductase.

GO:0000334; Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity.
GO:0008198; Molecular function: ferrous iron binding.

From: 3HAO_RALME (Q1LCS4)
Key		From		To		Description		Condition		FTGroup
METAL		51		51		Iron 1; catalytic (By similarity)		H
METAL		57		57		Iron 1; catalytic (By similarity)		E
METAL		95		95		Iron 1; catalytic (By similarity)		H
METAL		125		125		Iron 2 (By similarity)		C
METAL		128		128		Iron 2 (By similarity)		C
METAL		162		162		Iron 2 (By similarity)		C
METAL		165		165		Iron 2 (By similarity)		C
BINDING		47		47		Dioxygen (By similarity)		R
BINDING		57		57		Substrate (By similarity)		E
BINDING		99		99		Substrate (By similarity)		R
BINDING		110		110		Substrate (By similarity)		E

Size range:	174-189 amino acids
Related UniRules:	None
Template:	Q1LCS4 (3HAO_RALME); Q83V26 (3HAO_PSEFL): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALME