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HAMAP rule MF_00825

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General rule information [?]

Accession MF_00825
Dates 21-JUN-2006 (Created)
1-JUN-2023 (Last updated, Version 22)
Name 3_HAO
Scope(s) Bacteria
Template(s) Q1LCS4 (3HAO_CUPMC); Q83V26 (3HAO_PSEFL); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00825 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier 3HAO
Protein name RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase;
                 EC=1.13.11.6;
AltName: Full=3-hydroxyanthranilate oxygenase;
                 Short=3-HAO;
AltName: Full=3-hydroxyanthranilic acid dioxygenase;
                 Short=HAD;
Gene name Name=nbaC;

Comments [?]

FUNCTIONCatalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
CATALYTIC ACTIVITY Reaction=3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde; Xref=Rhea:RHEA:17953, ChEBI:CHEBI:15379, ChEBI:CHEBI:36559, ChEBI:CHEBI:77612; EC=1.13.11.6;
case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 Fe(2+) ions per subunit.;
else case <FTGroup:1> or <FTGroup:2>
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
end case
PATHWAYCofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
case <OC:Pseudomonadota>
SUBUNITHomodimer.
end case
SIMILARITYBelongs to the 3-HAO family.

Keywords [?]


Gene Ontology [?]

GO:0000334; Molecular function:3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0008198; Molecular function:ferrous iron binding
GO:0006569; Biological process:tryptophan catabolic process
GO:0019805; Biological process:quinolinate biosynthetic process
GO:0034354; Biological process:'de novo' NAD biosynthetic process from tryptophan
GO:0043420; Biological process:anthranilate metabolic process

Cross-references [?]

Pfam PF06052; 3-HAO; 1;
NCBIfam TIGR03037; Anthran_nbaC; 1;

Features [?]

From: 3HAO_CUPMC (Q1LCS4)
Key From To Description Tag Condition FTGroup
BINDING 51 51 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="1"
/ligand_note="catalytic"
H 1
BINDING 57 57 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="1"
/ligand_note="catalytic"
E 1
BINDING 95 95 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="1"
/ligand_note="catalytic"
H 1
BINDING 125 125 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="2"
C 2
BINDING 128 128 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="2"
C 2
BINDING 162 162 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="2"
C 2
BINDING 165 165 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_label="2"
C 2
BINDING 47 47 /ligand="O2"
/ligand_id="ChEBI:CHEBI:15379"
R
BINDING 57 57 /ligand="substrate" E
BINDING 99 99 /ligand="substrate" R
BINDING 110 110 /ligand="substrate" E

Additional information [?]

Size range 174-189 amino acids
Related rules None
Fusion Nter: None Cter: None



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