HAMAP rule MF_00835
General rule information
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Accession | MF_00835 |
Dates | 27-JUN-2011 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | BioC |
Scope(s) |
Bacteria |
Template(s) | P12999 (BIOC_ECOLI); P36571 (BIOC_SERMA); [ Recover all ] |
Triggered by |
HAMAP; MF_00835 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | BIOC |
Protein name | RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase; Short=Malonyl-ACP O-methyltransferase; EC=2.1.1.197; AltName: Full=Biotin synthesis protein BioC; |
Gene name | Name=bioC; |
Comments
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FUNCTION | Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. |
CATALYTIC ACTIVITY | Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA- COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=2.1.1.197; |
PATHWAY | Cofactor biosynthesis; biotin biosynthesis. |
SIMILARITY | Belongs to the methyltransferase superfamily. |
Keywords
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Gene Ontology
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GO:0010340; Molecular function:carboxyl-O-methyltransferase activity |
GO:0009102; Biological process:biotin biosynthetic process |
Cross-references
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PROSITE | PS00599; AA_TRANSFER_CLASS_2; 1; |
Pfam | PF08241; Methyltransf_11; 1; |
Pfam | PF08242; Methyltransf_12; 1; |
NCBIfam | TIGR02072; BioC; 1; |
Features
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Additional information
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Size range | 245-350 amino acids |
Related rules |
None |
Fusion | Nter: MF_01260 (BioH) Cter: MF_00336 (BioD); <Unknown> |