Due to maintenance work, this service will not be available Thursday September 18th between 1pm and 4am CEST.
Annotation rule MF_00835
Send feedback

General rule information [?]

Accession MF_00835
Dates 27-JUN-2011 (Created)
11-JUN-2013 (Last updated, Version 3)
Name BioC
Scope Bacteria

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase;
Short=Malonyl-ACP O-methyltransferase;
AltName: Full=Biotin synthesis protein BioC;
Gene name

Comments [?]

Function Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity).
Catalytic activity S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.
Pathway Cofactor biosynthesis; biotin biosynthesis.
Similarity Belongs to the methyltransferase superfamily.

Keywords [?]

Gene Ontology [?]

GO:0010340; Molecular function: carboxyl-O-methyltransferase activity.
GO:0009102; Biological process: biotin biosynthetic process.

Cross-references [?]

Pfam PF08241; Methyltransf_11; 1;
PF08242; Methyltransf_12; 1;
TIGRFAMs TIGR02072; BioC; 1;

Additional information [?]

Size range 245-350 amino acids
Related rules None
Templates P12999 (BIOC_ECOLI); P36571 (BIOC_SERMA): [Recover all]
Fusion Nter: MF_01260 (BioH); Cter: MF_00336 (BioD), <Unknown>