HAMAP rule MF_00905
General rule information
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| Accession | MF_00905 |
| Dates | 17-AUG-2011 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Name | cAMP_phosphodiest_CpdA |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0AEW4 (CPDA_ECOLI); P44685 (CPDA_HAEIN); Q6XBH1 (GPDQ_KLEAE); P9WP65 (CNPD3_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00905 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CPDA |
| Protein name | RecName: Full=3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Short=3',5'-cyclic AMP phosphodiesterase; Short=cAMP phosphodiesterase; EC=3.1.4.53; |
| Gene name | Name=cpdA; |
Comments
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| FUNCTION | Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. |
| CATALYTIC ACTIVITY | Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 Fe(2+) ions per subunit.; |
| SIMILARITY | Belongs to the cyclic nucleotide phosphodiesterase class- III family. |
Keywords
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Gene Ontology
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| GO:0004115; Molecular function:3',5'-cyclic-AMP phosphodiesterase activity |
| GO:0046872; Molecular function:metal ion binding |
| GO:0000166; Molecular function:nucleotide binding |
Cross-references
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| Pfam | PF00149; Metallophos; 1; |
Features
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| From: CPDA_ECOLI (P0AEW4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 94 | 95 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
N-H | ||||||||
| BINDING | 22 | 22 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
D | ||||||||
| BINDING | 24 | 24 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
H | ||||||||
| BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
D | ||||||||
| BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
D | ||||||||
| BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
N | ||||||||
| BINDING | 164 | 164 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
H | ||||||||
| BINDING | 203 | 203 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
H | ||||||||
| BINDING | 205 | 205 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
H | ||||||||
| BINDING | 24 | 24 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
H | ||||||||
| BINDING | 64 | 64 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
D | ||||||||
| BINDING | 205 | 205 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
H | ||||||||
Additional information
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| Size range | 240-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |