HAMAP rule MF_00907
General rule information
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| Accession | MF_00907 |
| Dates | 29-SEP-2011 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | Thioesterase_EntH |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0A8Y8 (ENTH_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00907 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ENTH |
| Protein name | RecName: Full=Proofreading thioesterase EntH; EC=3.1.2.-; AltName: Full=Enterobactin synthase component H; |
| Gene name | Name=entH; |
Comments
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| FUNCTION | Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. |
| PATHWAY | Siderophore biosynthesis; enterobactin biosynthesis. |
| SUBUNIT | Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thioesterase PaaI family. |
Keywords
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Gene Ontology
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| GO:0016790; Molecular function:thiolester hydrolase activity |
| GO:0009239; Biological process:enterobactin biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: ENTH_ECOLI (P0A8Y8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 63 | 63 | /note="Nucleophile or proton acceptor" | E | ||||||||
Additional information
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| Size range | 137-139 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |