HAMAP rule MF_00913
General rule information
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Accession | MF_00913 |
Dates | 23-NOV-2011 (Created)
1-JUN-2023 (Last updated, Version 15) |
Name | PGT_FtsW_proteobact |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0ABG4 (FTSW_ECOLI); P0ABG7 (RODA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00913 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | FTSW |
Protein name | RecName: Full=Probable peptidoglycan glycosyltransferase FtsW; Short=PGT; EC=2.4.1.129; AltName: Full=Cell division protein FtsW; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase; |
Gene name | Name=ftsW; |
Comments
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FUNCTION | Peptidoglycan polymerase that is essential for cell division. |
CATALYTIC ACTIVITY | Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum. |
SIMILARITY | Belongs to the SEDS family. FtsW subfamily. |
Keywords
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Gene Ontology
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GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity |
GO:0043093; Biological process:FtsZ-dependent cytokinesis |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0032153; Cellular component:cell division site |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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PROSITE | PS00428; FTSW_RODA_SPOVE; 1; |
Pfam | PF01098; FTSW_RODA_SPOVE; 1; |
NCBIfam | TIGR02614; FtsW; 1; |
General | Transmembrane; -; 8-10; |
Features
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Additional information
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Size range | 353-524 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL. |