Annotation rule MF_00917
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General rule information [?]

Accession MF_00917
Dates 8-FEB-2012 (Created)
10-OCT-2014 (Last updated, Version 5)
Name QueE
Scope Bacteria
Archaea
Template O31677 (QUEE_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
QUEE
case <OC:Bacteria>
Protein name
RecName: Full=7-carboxy-7-deazaguanine synthase;
Short=CDG synthase;
EC=4.3.99.3;
AltName: Full=Queuosine biosynthesis protein QueE;
else case <OC:Archaea>
Protein name
RecName: Full=7-carboxy-7-deazaguanine synthase;
Short=CDG synthase;
EC=4.3.99.3;
AltName: Full=Archaeosine biosynthesis protein QueE;
end case
Gene name
queE

Comments [?]

Function Catalyzes the conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG).
Catalytic activity 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3).
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
S-adenosyl-L-methionine
Note: Binds 1 S-adenosyl-L-methionine per subunit.
Pathway Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Similarity Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.

Keywords [?]

case <OC:Bacteria>
end case

Gene Ontology [?]

GO:0016840; Molecular function: carbon-nitrogen lyase activity.
GO:0051536; Molecular function: iron-sulfur cluster binding.
case <OC:Bacteria>
GO:0008616; Biological process: queuosine biosynthetic process.
end case

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
TIGRFAMs TIGR03365; Bsubt_queE; 1;
TIGR03963; RSAM_QueE_Clost; 1;
PIRSF PIRSF000370; QueE; 1;

Features [?]

From: QUEE_BACSU (O31677)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     34     34       Iron-sulfur (4Fe-4S-S-AdoMet)     C  
METAL     38     38       Iron-sulfur (4Fe-4S-S-AdoMet)     C  
METAL     41     41       Iron-sulfur (4Fe-4S-S-AdoMet)     C  

Additional information [?]

Size range 180-290 amino acids
Related rules None
Fusion None