Annotation rule MF_00936
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General rule information [?]

Accession MF_00936
Dates 21-JAN-2013 (Created)
11-DEC-2015 (Last updated, Version 6)
Name ParC_type1
Scope Bacteria; Proteobacteria
Templates P0AFI2 (PARC_ECOLI); P72525 (PARC_STRPN): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PARC
Protein name
RecName: Full=DNA topoisomerase 4 subunit A;
EC=5.99.1.3;
AltName: Full=Topoisomerase IV subunit A;
Gene name
parC

Comments [?]

Function Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Subunit Heterotetramer composed of ParC and ParE.
Subcellular location Cell membrane; Peripheral membrane protein.
Similarity Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
GO:0019897; Cellular component: extrinsic component of plasma membrane.

Cross-references [?]

Pfam PF03989; DNA_gyraseA_C; 2-3;
PF00521; DNA_topoisoIV; 1;
TIGRFAMs TIGR01062; parC_Gneg; 1;

Features [?]

From: PARC_ECOLI (P0AFI2)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     120     120       O-(5'-phospho-DNA)-tyrosine intermediate     Y  
SITE (Optional)     39     39       Interaction with DNA     K  
SITE (Optional)     75     75       Interaction with DNA     H  
SITE (Optional)     77     77       Interaction with DNA     H  
SITE     119     119       Transition state stabilizer     R  

Additional information [?]

Size range 710-820 amino acids
Related rules None
Fusion None
Comments See MF_00937 for ParC type 2 subfamily.