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HAMAP rule MF_00938

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General rule information [?]

Accession MF_00938
Dates 23-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 12)
Name ParE_type1
Scope(s) Bacteria
Pseudomonadota
Template(s) P20083 (PARE_ECOLI); Q59961 (PARE_STRPN); [ Recover all ]
Triggered by HAMAP; MF_00938 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PARE
Protein name RecName: Full=DNA topoisomerase 4 subunit B;
                 EC=5.6.2.2;
AltName: Full=Topoisomerase IV subunit B;
Gene name Name=parE;

Comments [?]

FUNCTIONTopoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;
SUBUNITHeterotetramer composed of ParC and ParE.
SIMILARITYBelongs to the type II topoisomerase family. ParE type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0007059; Biological process:chromosome segregation
GO:0006265; Biological process:DNA topological change

Cross-references [?]

PROSITE PS00177; TOPOISOMERASE_II; 1;
PROSITE PS50880; TOPRIM; 1;
Pfam PF00204; DNA_gyraseB; 1;
Pfam PF00986; DNA_gyraseB_C; 1;
Pfam PF02518; HATPase_c; 1;
Pfam PF01751; Toprim; 1;
PRINTS PR00418; TPI2FAMILY; 1;
NCBIfam TIGR01055; parE_Gneg; 1;

Features [?]

From: PARE_ECOLI (P20083)
Key From To Description Tag Condition FTGroup
BINDING 110 116 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-L-[HN]-G-V-G-x
BINDING 5 5 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
Y
BINDING 42 42 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N
BINDING 69 69 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D
BINDING 334 334 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
SITE 446 446 /note="Interaction with DNA" N
SITE 497 497 /note="Interaction with DNA" H
SITE 615 615 /note="Interaction with DNA" R

Additional information [?]

Size range 600-750 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_00939 for ParE type 2 subfamily.



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