HAMAP rule MF_00941
General rule information
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| Accession | MF_00941 |
| Dates | 7-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 8) |
| Name | GDPMH_gmm |
| Scope(s) |
Bacteria Enterobacteriaceae |
| Template(s) | P32056 (GMM_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00941 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GMM |
| Protein name | RecName: Full=GDP-mannose mannosyl hydrolase; Short=GDPMH; EC=3.6.1.-; |
| Gene name | Name=gmm; |
Comments
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| FUNCTION | Hydrolyzes GDP-mannose. |
| CATALYTIC ACTIVITY | Reaction=GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+); Xref=Rhea:RHEA:28102, ChEBI:CHEBI:4208, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:58189; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the Nudix hydrolase family. |
Keywords
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| Hydrolase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0008727; Molecular function:GDP-mannose mannosyl hydrolase activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
Cross-references
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| PROSITE | PS51462; NUDIX; 1; |
| PROSITE | PS00893; NUDIX_BOX; 1; |
| Pfam | PF00293; NUDIX; 1; |
| PIRSF | PIRSF037599; GDPMH; 1; |
Features
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| From: GMM_ECOLI (P32056) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 2 | 3 | /ligand="substrate" | F-L | ||||||||
| BINDING | 49 | 49 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
G | 1 | |||||||
| BINDING | 69 | 69 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 122 | 122 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
Q | 1 | |||||||
| BINDING | 8 | 8 | /ligand="substrate" | F | ||||||||
| BINDING | 36 | 36 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 130-184 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |