HAMAP rule MF_00951
General rule information
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Accession | MF_00951 |
Dates | 13-MAR-2013 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | RfaH |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0AFW0 (RFAH_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00951 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RFAH |
Protein name | RecName: Full=Transcription antitermination protein RfaH; |
Gene name | Name=rfaH; |
Comments
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case <OC:Enterobacterales> | |
FUNCTION | Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. |
else | |
FUNCTION | Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. |
end case | |
SUBUNIT | Interacts with both the nontemplate DNA and the RNA polymerase (RNAP). |
SIMILARITY | Belongs to the RfaH family. |
Keywords
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Gene Ontology
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GO:0003677; Molecular function:DNA binding |
GO:0001073; Molecular function:transcription antitermination factor activity, DNA binding |
GO:0031564; Biological process:transcription antitermination |
Cross-references
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Features
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Additional information
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Size range | 150-224 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |