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HAMAP rule MF_00951

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General rule information [?]

Accession MF_00951
Dates 13-MAR-2013 (Created)
1-JUN-2023 (Last updated, Version 7)
Name RfaH
Scope(s) Bacteria
Pseudomonadota
Template(s) P0AFW0 (RFAH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00951 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RFAH
Protein name RecName: Full=Transcription antitermination protein RfaH;
Gene name Name=rfaH;

Comments [?]

case <OC:Enterobacterales>
FUNCTIONEnhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
else
FUNCTIONEnhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
end case
SUBUNITInteracts with both the nontemplate DNA and the RNA polymerase (RNAP).
SIMILARITYBelongs to the RfaH family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0001073; Molecular function:transcription antitermination factor activity, DNA binding
GO:0031564; Biological process:transcription antitermination

Cross-references [?]

Pfam PF02357; NusG; 1;
NCBIfam TIGR01955; RfaH; 1;

Features [?]


Additional information [?]

Size range 150-224 amino acids
Related rules None
Fusion Nter: None Cter: None



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