HAMAP rule MF_00955
General rule information
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| Accession | MF_00955 |
| Dates | 11-APR-2013 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | GDP_Man_dehydratase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0AC88 (GM4D_ECOLI); Q51366 (GM4D_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00955 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GM4D |
| Protein name | RecName: Full=GDP-mannose 4,6-dehydratase; EC=4.2.1.47; AltName: Full=GDP-D-mannose dehydratase; |
| Gene name | Name=gmd; |
Comments
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| FUNCTION | Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. |
| CATALYTIC ACTIVITY | Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O; Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527, ChEBI:CHEBI:57964; EC=4.2.1.47; |
| COFACTOR | Name=NADP(+); Xref=ChEBI:CHEBI:58349; |
| SIMILARITY | Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. |
Keywords
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Gene Ontology
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| GO:0008446; Molecular function:GDP-mannose 4,6-dehydratase activity |
| GO:0070401; Molecular function:NADP+ binding |
Cross-references
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Features
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| From: GMD2_ARATH (P0AC88) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 35 | 40 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
G-x-x-G-Q-D | ||||||||
| BINDING | 91 | 92 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
D-[LMIV] | ||||||||
| BINDING | 113 | 117 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
L-x-[AG]-x-[ST] | ||||||||
| ACT_SITE | 162 | 162 | [TS] | |||||||||
| ACT_SITE | 164 | 164 | /note="Nucleophile" | E | ||||||||
| ACT_SITE | 185 | 185 | /note="Nucleophile" | Y | ||||||||
| BINDING | 128 | 128 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
Y | ||||||||
| BINDING | 189 | 189 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
| BINDING | 215 | 215 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
H | ||||||||
| BINDING | 220 | 220 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
R | ||||||||
Additional information
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| Size range | 300-430 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |