HAMAP rule MF_00959
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00959 |
| Accession | MF_00959 |
| Dates | 30-APR-2013 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | Sigma70_RpoS |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P13445 (RPOS_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00959 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RPOS |
| Protein name | RecName: Full=RNA polymerase sigma factor RpoS; AltName: Full=Sigma S; AltName: Full=Sigma-38; |
| Gene name | Name=rpoS; |
Comments
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| FUNCTION | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. |
| SUBUNIT | Interacts with the RNA polymerase core enzyme. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the sigma-70 factor family. RpoS subfamily. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0016987; Molecular function:sigma factor activity |
| GO:0010468; Biological process:regulation of gene expression |
| GO:0006352; Biological process:DNA-templated transcription initiation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00715; SIGMA70_1; 1; |
| PROSITE | PS00716; SIGMA70_2; 1; |
| Pfam | PF00140; Sigma70_r1_2; 1; |
| Pfam | PF04542; Sigma70_r2; 1; |
| Pfam | PF04539; Sigma70_r3; 1; |
| Pfam | PF04545; Sigma70_r4; 1; |
| PRINTS | PR00046; SIGMA70FCT; 1; |
| NCBIfam | TIGR02394; rpoS_proteo; 1; |
| NCBIfam | TIGR02937; sigma70-ECF; 1; |
Features
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| From: RPOS_ECOLI (P13445) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 288 | 307 | /note="H-T-H motif" | |||||||||
| REGION | 56 | 89 | /note="Sigma-70 factor domain-1" | |||||||||
| REGION | 94 | 164 | /note="Sigma-70 factor domain-2" | |||||||||
| REGION | 174 | 249 | /note="Sigma-70 factor domain-3" | |||||||||
| REGION | 262 | 315 | /note="Sigma-70 factor domain-4" | |||||||||
| MOTIF | 118 | 121 | /note="Interaction with polymerase core subunit RpoC" | D-L-[IV]-[ED] | ||||||||
Additional information
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| Size range | 250-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |