HAMAP rule MF_01001

General rule information [?]

Accession	MF_01001
Dates	7-FEB-2002 (Created) 1-JUN-2023 (Last updated, Version 25)
Name	WecG_RffM
Scope(s)	Bacteria Enterobacterales
Template(s)	P27836 (WECG_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01001 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	WECG
Protein name	RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase; Short=UDP-ManNAcA transferase; EC=2.4.1.180;
Gene name	Name=wecG; Synonyms=rffM;

Comments [?]

FUNCTION	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
CATALYTIC ACTIVITY	Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D- ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP; Xref=Rhea:RHEA:28366, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61495, ChEBI:CHEBI:62959, ChEBI:CHEBI:70731; EC=2.4.1.180;
PATHWAY	Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
SIMILARITY	Belongs to the glycosyltransferase 26 family.

Keywords [?]

Gene Ontology [?]

GO:0047241; Molecular function:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity

GO:0009246; Biological process:enterobacterial common antigen biosynthetic process

Cross-references [?]

Pfam	PF03808; Glyco_tran_WecB; 1;
NCBIfam	TIGR00696; WecB_tagA_cpsF; 1;

Features [?]

Additional information [?]