HAMAP rule MF_01005
General rule information
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| Accession | MF_01005 |
| Dates | 15-FEB-2002 (Created)
19-NOV-2022 (Last updated, Version 41) |
| Name | BtuD |
| Scope(s) |
Bacteria Enterobacterales Vibrionaceae |
| Template(s) | P06611 (BTUD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01005 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BTUD |
| Protein name | RecName: Full=Vitamin B12 import ATP-binding protein BtuD; EC=7.6.2.8; AltName: Full=Vitamin B12-transporting ATPase; |
| Gene name | Name=btuD; |
Comments
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| FUNCTION | Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. |
| CATALYTIC ACTIVITY | Reaction=an R-cob(III)alamin(out) + ATP + H2O = ADP + an R- cob(III)alamin(in) + H(+) + phosphate; Xref=Rhea:RHEA:17873, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:140785, ChEBI:CHEBI:456216; EC=7.6.2.8; |
| SUBUNIT | The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF). |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
| SIMILARITY | Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family. |
Keywords
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| ATP-binding | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Nucleotide-binding | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Transport | |
Gene Ontology
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| GO:0015420; Molecular function:ABC-type vitamin B12 transporter activity |
| GO:0015889; Biological process:cobalamin transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
Features
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| From: BTUD_ECOLI (P06611) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 33 | 40 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-P-N-G-[ASC]-G-K-S | ||||||||
Additional information
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| Size range | 249-255 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |